Brain Machine Interfaces combining Microelectrode Arrays with Nanostructured Optical Biochemical Sensors

被引:0
|
作者
Hajj-Hassan, Mohamad [1 ]
Gonzalez, Timothy [2 ]
Ghafar-Zadeh, Ebrahim [1 ]
Chodavarapu, Vamsy [1 ]
Musallam, Sam [1 ,3 ]
Andrews, Mark [2 ]
机构
[1] McGill Univ, Dept Elect & Comp Engn, 3480 Univ St, Montreal, PQ H3A 2A7, Canada
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
[3] McGill Univ, Dept Physiol, Montreal, PQ H3G 1Y6, Canada
来源
NANOSCALE IMAGING, SENSING, AND ACTUATION FOR BIOMEDICAL APPLICATIONS VI | 2009年 / 7188卷
基金
加拿大自然科学与工程研究理事会;
关键词
Direct-write; Hybrid xerogels; MEMS; Oxygen sensors; Sensor microsystem; Brain machine interface; Silicon microelectrodes; Neural recording; CHEMICAL SENSORS; WAVE-GUIDES;
D O I
10.1117/12.808032
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Neural microelectrodes are an important component of neural prosthetic systems which assist paralyzed patients by allowing them to operate computers or robots using their neural activity. These microelectrodes are also used in clinical settings to localize the locus of seizure initiation in epilepsy or to stimulate sub-cortical structures in patients with Parkinson's disease. In neural prosthetic systems, implanted microelectrodes record the electrical potential generated by specific thoughts and relay the signals to algorithms trained to interpret these thoughts. In this paper, we describe novel elongated multi-site neural electrodes that can record electrical signals and specific neural biomarkers and that can reach depths greater than 8mm in the sulcus of non-human primates (monkeys). We hypothesize that additional signals recorded by the multimodal probes will increase the information yield when compared to standard probes that record just electropotentials. We describe integration of optical biochemical sensors with neural microelectrodes. The sensors are made using sol-gel derived xerogel thin films that encapsulate specific biomarker responsive luminophores in their nanostructured pores. The desired neural biomarkers are O2, pH, K+, and Na+ ions. As a prototype, we demonstrate direct-write patterning to create oxygen-responsive xerogel waveguide structures on the neural microelectrodes. The recording of neural biomarkers along with electrical activity could help the development of intelligent and more user-friendly neural prosthesis/brain machine interfaces as well as aid in providing answers to complex brain diseases and disorders.
引用
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页数:9
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