Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements

被引：0
|
作者：
Sachdev, Ritesh [1 ]
Agarwal, Naveen [1 ]
Khan, Mohd Ateek [1 ]
Kumar, Anil [1 ]
机构：
[1] Oncquest Labs Pvt Ltd, New Delhi 110029, India
来源：
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2015年 / 31卷 / 01期
关键词：
Acute leukemia; Infantile; Monoblastic; MLL;
D O I：
10.1007/s12288-012-0205-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 7 month infant presented with fever and breathlessness with raised total counts. Examination revealed 90 % blasts with prominent nucleoli. Flow cytometry revealed a tight cluster in the monocytic region. The blasts showed homogenous bright CD 33/4/64/HLA D with heterogeneous expression of CD14/15/11c. Blasts were negative for CD13/MPO/Cytoplasmic CD3/19/7/34/117/5/22/TdT/CD 61/41. FISH revealed MLL gene rearrangements in the blasts. No evidence of Down's syndrome on cytogenetic studies was noted. Diagnosis of Infantile acute monoblastic leukemia was made. These leukemias are rare in infants and are associated with a poor outcome.
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收藏
页码：146 / 147
页数：2
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