Imbalanced cholesterol metabolism in Alzheimer's disease

被引：106
|
作者：
Zhao Xue-shan [1 ]
Peng Juan [1 ]
Wu Qi [1 ]
Ren Zhong [1 ]
Pan Li-hong [1 ]
Tang Zhi-han [1 ]
Jiang Zhi-sheng [1 ]
Wang Gui-xue [2 ]
Liu Lu-shan [1 ,2 ]
机构：
[1] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China
[2] Chongqing Univ, Coll Bioengn, Chongqing 400030, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2016年 / 456卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; A beta; Cholesterol; apoE; PCSK9; LRP1; AMYLOID-BETA-PEPTIDE; RECEPTOR-RELATED PROTEIN-1; BLOOD-BRAIN-BARRIER; APOLIPOPROTEIN-E; RISK-FACTORS; STATIN USE; PCSK9; ASSOCIATION; PLASMA; LDL;
D O I：
10.1016/j.cca.2016.02.024
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease that is mainly caused by beta-amyloid accumulation. A large number of studies have shown that elevated cholesterol levels may perform a function in AD pathology, and several cholesterol-related gene polymorphisms are associated with this disease. Although numerous studies have shown the important function of cholesterol in AD pathogenesis and development, the underlying mechanism remains unclear. To further elucidate cholesterol metabolism disorder and AD, we first, review metabolism and regulation of the cholesterol in the brain. Second, we summarize the literature stating that hypercholesterolemia is one of the risk factors of AD. Third, we discuss the main mechanisms of abnormal cholesterol metabolism that increase the risk of AD. Finally, the relationships between AD and apolipoprotein E, PCSK9, and LRP1 are discussed in this article. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：107 / 114
页数：8
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