Vaterite deposition on biodegradable polymer foam scaffolds for inducing bone-like hydroxycarbonate apatite coatings

被引:21
|
作者
Maeda, H.
Maquet, V.
Kasuga, T.
Chen, Q. Z.
Roether, J. A.
Boccaccini, A. R.
机构
[1] Univ London Imperial Coll Sci & Technol, Dept Mat, London SW7 2BP, England
[2] Nagoya Inst Technol, Grad Sch Engn, Dept Mat Sci & Engn, Nagoya, Aichi 4668555, Japan
[3] Univ Liege, Interfac Ctr Biomat, Ctr Educ & Res Macromol, B-4000 Cointe Ougree, Belgium
基金
日本学术振兴会;
关键词
D O I
10.1007/s10856-007-3108-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Hydroxycarbonate apatite (HCA) coatings on the surface of bioresorbable materials for bone tissue engineering scaffolds were produced using macroporous poly(DL-lactide) (PDLLA) foams impregnated by calcium carbonate in vaterite crystalline form. Stable and homogeneous vaterite deposition on PDLLA foams was achieved using a slurry dipping technique. In vitro studies in simulated body fluid (SBF) were performed to induce formation of (HCA) on the surface of vaterite/PDLLA composite foams. HCA was detected after immersion of foams in SBF for 7 days. Hence, depositing vaterite on materials followed by immersion in SBF is confirmed to induce HCA coatings on the surface of the material. The HCA coated, bioactive and resorbable PDLLA foams are intended for use as bone tissue engineering scaffolds.
引用
收藏
页码:2269 / 2273
页数:5
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