Survival and prognostic factors for glioblastoma multiforme: Retrospective single-institutional study

被引:27
|
作者
Ghosh, M. [1 ]
Shubham, S. [1 ]
Mandal, K. [1 ]
Trivedi, V [1 ]
Chauhan, R. [1 ]
Naseera, S. [1 ]
机构
[1] Mahavir Canc Sansthan, Dept Radiat Oncol, Patna, Bihar, India
关键词
Glioblastoma multiforme; prognostic factors; survival; temozolomide; NEWLY-DIAGNOSED GLIOBLASTOMA; ADJUVANT TEMOZOLOMIDE; MULTIVARIATE-ANALYSIS; PLUS CONCOMITANT; RADIOTHERAPY; THERAPY; EXPERIENCE; RESECTION; EXTENT; TUMORS;
D O I
10.4103/ijc.IJC_157_17
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
INTRODUCTION: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. The standard management has been maximum surgical resection followed by adjuvant radiotherapy with concurrent chemotherapy followed by adjuvant chemotherapy. Although the survival rate of patients with GBM has improved with recent advancements in treatment, the prognosis remains generally poor. The median survival rates are in the range of 9-12 months and 2-year survival rates are in the range of 8%-12%. MATERIALS AND METHODS: A single-institution retrospective review of 61 patients of GBM from 2012 to 2014. Data regarding patient factors, disease factors, and treatment factors were collected and survival has been calculated. RESULTS: A total of 61 patients with GBM were analyzed. GBM is commonly seen in sixth decade of life. Male to female ratio is 2.6: 1. The right side of the brain is commonly involved with right frontal lobe being the most common site. The median follow-up was 4.6 months. The median survival of our patients was 8 months. The 1-year and 2-year survival rates were 20% and 3.27%, respectively. CONCLUSIONS: The overall survival and prognosis in patients with GBM remains poor despite of constant research and studies. Concurrent chemoradiotherapy followed by adjuvant chemotherapy with temozolomide should be used after maximal resection to improve the survival.
引用
收藏
页码:362 / 367
页数:6
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