Site-Selective 1,4-Difunctionalization of Nitrogen Heteroaromatics for Constructing Vinylidene Heterocycles

被引：9

作者：

He, Qianlin ^{[1
]}

Zhong, Mingli ^{[2
]}

Chen, Zhichao ^{[1
]}

Liao, Chuyi ^{[1
]}

Xie, Feng ^{[1
]}

Zhu, Zhongzhi ^{[1
]}

Chen, Xiuwen ^{[1
]}

机构：

[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

[2] Guilin Med Univ, Coll Pharm, Guilin 541199, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 02期

关键词：

A one-pot; dearomatization; N-heteroaromatics; difunctionalization; NUCLEOPHILIC DEAROMATIZATION; PYRIDINES; METAL; ARYLATION;

D O I：

10.1002/adsc.202101098

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A one-pot protocol for constructing 1,4-difunctionalized quinoline/pyridine derivatives via the reaction of N-heteroaromatics, alkyl halides, and active methylene/methyl compounds was developed. The transformation involves dearomative functionalization of an in situ-activated N-heteroaromatic to construct new C-N and C=C bonds. This reaction has a broad substrate scope and functional group tolerance.

引用

页码：459 / 463

页数：5

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