Extra-pulmonary small cell carcinoma in the head and neck setting: The role of prophylactic cranial irradiation

被引：5

作者：

Mason, Matthew ^{[1
]}

Giuliani, Meredith ^{[1
]}

Huang, Shao Hui ^{[1
]}

Xu, Wei ^{[6
]}

Hope, Andrew ^{[1
]}

Kim, John ^{[1
]}

Bayley, Andrew ^{[1
]}

Cho, B. C. John ^{[1
]}

Goldstein, David ^{[2
]}

Jang, Raymond W. ^{[3
]}

Ordonez, Bayardo Perez ^{[4
]}

Wajstaub, Sandra ^{[5
]}

Waldron, John ^{[1
]}

Dinniwell, Robert ^{[1
]}

O'Sullivan, Brian ^{[1
]}

Ringash, Jolie ^{[1
]}

机构：

[1] Univ Toronto, Dept Radiat Oncol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada

[2] Univ Toronto, Dept Dept Otolaryngol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada

[3] Univ Toronto, Div Med Oncol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada

[4] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON M5T 2M9, Canada

[5] Cape Breton Canc Ctr, Dept Radiat Oncol, Sydney, NS B1P 1P3, Canada

[6] Univ Toronto, Dept Biostat, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada

来源：

ORAL ONCOLOGY | 2015年 / 51卷 / 06期

关键词：

Small cell carcinoma; Head and neck carcinoma; Prophylactic cranial irradiation; Chemoradiotherapy; Patterns of failure; Neurocognition; IMRT; Brain metastases; Local failure; Whole brain radiation; CANCER;

D O I：

10.1016/j.oraloncology.2015.03.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head-and-neck small cell carcinoma (HN-SmCC) is a rare entity and there is limited data to support management decisions. The role of prophylactic cranial irradiation (PCI) remains controversial. A retrospective review of 21 consecutive HN-SmCCs was performed. No case received PCI. The 2-year overall survival, local, regional and distant control rates were 65%, 94%, 88%, and 76% respectively. Despite no patient receiving PCI, brain metastases were uncommon (n = 2) and routine use of PCI is not justified in this population. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：E57 / E59

页数：3

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