Extra-pulmonary small cell carcinoma in the head and neck setting: The role of prophylactic cranial irradiation

被引：5
|
作者：
Mason, Matthew [1 ]
Giuliani, Meredith [1 ]
Huang, Shao Hui [1 ]
Xu, Wei [6 ]
Hope, Andrew [1 ]
Kim, John [1 ]
Bayley, Andrew [1 ]
Cho, B. C. John [1 ]
Goldstein, David [2 ]
Jang, Raymond W. [3 ]
Ordonez, Bayardo Perez [4 ]
Wajstaub, Sandra [5 ]
Waldron, John [1 ]
Dinniwell, Robert [1 ]
O'Sullivan, Brian [1 ]
Ringash, Jolie [1 ]
机构：
[1] Univ Toronto, Dept Radiat Oncol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada
[2] Univ Toronto, Dept Dept Otolaryngol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada
[3] Univ Toronto, Div Med Oncol, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada
[4] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON M5T 2M9, Canada
[5] Cape Breton Canc Ctr, Dept Radiat Oncol, Sydney, NS B1P 1P3, Canada
[6] Univ Toronto, Dept Biostat, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5T 2M9, Canada
来源：
ORAL ONCOLOGY | 2015年 / 51卷 / 06期
关键词：
Small cell carcinoma; Head and neck carcinoma; Prophylactic cranial irradiation; Chemoradiotherapy; Patterns of failure; Neurocognition; IMRT; Brain metastases; Local failure; Whole brain radiation; CANCER;
D O I：
10.1016/j.oraloncology.2015.03.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head-and-neck small cell carcinoma (HN-SmCC) is a rare entity and there is limited data to support management decisions. The role of prophylactic cranial irradiation (PCI) remains controversial. A retrospective review of 21 consecutive HN-SmCCs was performed. No case received PCI. The 2-year overall survival, local, regional and distant control rates were 65%, 94%, 88%, and 76% respectively. Despite no patient receiving PCI, brain metastases were uncommon (n = 2) and routine use of PCI is not justified in this population. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：E57 / E59
页数：3
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