H2SO4-Silica Catalyzed One-Pot and Efficient Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions

被引：7

作者：

Pourmousavi, Seied Ali ^{[1
]}

Hasani, Maryam ^{[1
]}

机构：

[1] Damghan Univ, Sch Chem, Damghan 3671641167, Iran

来源：

E-JOURNAL OF CHEMISTRY | 2011年 / 8卷

关键词：

H2SO4-Silica; Aldehydes; 1,3-Dicarbonyl compounds; Dihydropyrimidinone; Biginelli reaction; Solvent free conditions; CALCIUM-CHANNEL BLOCKERS; HIGH-YIELD SYNTHESIS; REUSABLE CATALYST; SULFURIC-ACID; BIGINELLI REACTION; IMPROVED PROTOCOL; SILICA; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; TRIBROMIDE; CHLORIDE;

D O I：

10.1155/2011/158612

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of giving good yields and requiring short reaction times.

引用

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页码：S462 / S466

页数：5

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