Visible-light-induced photocatalytic difluoroalkylation of 3-substituted benzo[d]isoxazoles via direct and regioselective C-H functionalization

被引：8

作者：

Hua, Ming-Qing ^{[1
]}

Mou, Fang-You ^{[1
]}

Wang, Nian-Hong ^{[1
]}

Chen, Yan ^{[1
]}

Xiong, Heng-Ying ^{[3
]}

Huang, Yan ^{[1
]}

Lei, Cheng-Lin ^{[4
]}

Zhang, Qi ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Hainan Univ, Hainan Prov Key Lab Fine Chem, Haikou 570228, Hainan, Peoples R China

[3] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Henan, Peoples R China

[4] Shuangliang Ecoenergy Syst Co Ltd, Wuxi 214431, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 51期

基金：

中国国家自然科学基金;

关键词：

Difluoroalkylation; Benzo[d]isoxazoles; Visible-light photocatalysis; Site-selectivity; CASCADE DIFLUOROALKYLATION; CYCLIZATION; DESIGN; ACCESS; CARBONYLATION; BENZISOXAZOLE; DERIVATIVES; FLUORINE; ALKENES; ARENES;

D O I：

10.1016/j.tetlet.2018.10.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The difluoroalkylation of unactivated benzo[d]isoxazoles with ethyl difluorobromoacetate by visible-light photoredox catalysis via direct and regioselective C-H functionalization has been efficiently achieved under mild reaction conditions. The difluoroalkylated adducts could be readily converted to a variety of corresponding CF2-containing heterocycles, demonstrating the synthetic utility of the present approach. (C) 2018 Published by Elsevier Ltd.

引用

页码：4449 / 4453

页数：5

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