Visible-light-induced photocatalytic difluoroalkylation of 3-substituted benzo[d]isoxazoles via direct and regioselective C-H functionalization

被引：8
|
作者：
Hua, Ming-Qing [1 ]
Mou, Fang-You [1 ]
Wang, Nian-Hong [1 ]
Chen, Yan [1 ]
Xiong, Heng-Ying [3 ]
Huang, Yan [1 ]
Lei, Cheng-Lin [4 ]
Zhang, Qi [1 ,2 ]
机构：
[1] Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Hainan Univ, Hainan Prov Key Lab Fine Chem, Haikou 570228, Hainan, Peoples R China
[3] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Henan, Peoples R China
[4] Shuangliang Ecoenergy Syst Co Ltd, Wuxi 214431, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 51期
基金：
中国国家自然科学基金;
关键词：
Difluoroalkylation; Benzo[d]isoxazoles; Visible-light photocatalysis; Site-selectivity; CASCADE DIFLUOROALKYLATION; CYCLIZATION; DESIGN; ACCESS; CARBONYLATION; BENZISOXAZOLE; DERIVATIVES; FLUORINE; ALKENES; ARENES;
D O I：
10.1016/j.tetlet.2018.10.007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The difluoroalkylation of unactivated benzo[d]isoxazoles with ethyl difluorobromoacetate by visible-light photoredox catalysis via direct and regioselective C-H functionalization has been efficiently achieved under mild reaction conditions. The difluoroalkylated adducts could be readily converted to a variety of corresponding CF2-containing heterocycles, demonstrating the synthetic utility of the present approach. (C) 2018 Published by Elsevier Ltd.
引用
收藏
页码：4449 / 4453
页数：5
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