T cell-mediated autoimmunity in immune thrombocytopenia

被引：22

作者：

Vrbensky, John R. ^{[1
]}

Nazy, Ishac ^{[1
,2
]}

Clare, Rumi ^{[1
]}

Larche, Mark ^{[1
]}

Arnold, Donald M. ^{[1
,2
,3
]}

机构：

[1] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, Hamilton, ON, Canada

[2] McMaster Univ, McMaster Ctr Transfus Res, Hamilton, ON, Canada

[3] Canadian Blood Serv, Hamilton, ON, Canada

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2022年 / 108卷 / 01期

关键词：

autoantibodies; autoimmunity; CD8(+) T cells; immune thrombocytopenia; platelets; HLA CLASS-I; PLATELET DESTRUCTION; APOPTOSIS; PURPURA; LYMPHOCYTES; ANTIGENS; IDENTIFICATION; EXPRESSION; CYTOTOXICITY; ACTIVATION;

D O I：

10.1111/ejh.13705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti-platelet autoantibodies, CD8(+) T cells have been implicated as a mechanism of platelet destruction. The current evidence for the existence of platelet-specific CD8(+) T cells in ITP is inconclusive. The purpose of this review is to summarize the studies that investigated CD8(+) T cells in ITP and to review the methods that have been used to detect autoreactive CD8(+) T cells in other autoimmune diseases.

引用

页码：18 / 27

页数：10

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