Requirement for p85α regulatory subunit of class IA PI3kinase and rac2 GTPase in myeloproliferative disease driven by activation loop mutant of KIT

被引：0
|
作者：
Munugalavadla, Veerendra [1 ]
Sims, Emily C. [1 ]
Lenz, Stephen D. [2 ]
Kapur, Reuben [1 ]
机构：
[1] Indiana Univ, Sch Med, Indianapolis, IN USA
[2] Purdue Univ, W Lafayette, IN USA
来源：
BLOOD | 2007年 / 110卷 / 11期
关键词：
D O I：
10.1182/blood.V110.11.89.89
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
89
引用
收藏
页码：35A / 35A
页数：1
相关论文
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  • [1] Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT
    Munugalavadla, Veerendra
    Sims, Emily C.
    Chan, Rebecca J.
    Lenz, Stephen D.
    Kapur, Reuben
    [J]. EXPERIMENTAL HEMATOLOGY, 2008, 36 (03) : 301 - 308
  • [2] Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI-3Kinase and Rac2 GTPase in regulating oncogenic kit induced transformation in acute myeloid leukemia and systemic mastocytosis.
    Munugalavadla, V.
    Sims, E. C.
    Kapur, R.
    [J]. PEDIATRIC RESEARCH, 2007, 62 (04) : 519 - 519
  • [3] Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
    Munugalavadla, Veerendra
    Sims, Emily C.
    Borneo, Jovencio
    Chan, Rebecca J.
    Kapur, Reuben
    [J]. BLOOD, 2007, 110 (05) : 1612 - 1620
  • [4] Class IA PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes
    Krishnan, Subha
    Mali, Raghuveer Singh
    Koehler, Karl R.
    Vemula, Sasidhar
    Chatterjee, Anindya
    Ghosh, Joydeep
    Ramdas, Baskar
    Ma, Peilin
    Hashino, Eri
    Kapur, Reuben
    [J]. PLOS ONE, 2012, 7 (01):
  • [5] p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
    Munugalavadla, V
    Borneo, J
    Ingram, DA
    Kapur, R
    [J]. BLOOD, 2005, 106 (01) : 103 - 109
  • [6] p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
    Krishnan, Subha
    Mali, Raghuveer Singh
    Ramdas, Baskar
    Sims, Emily
    Ma, Peilin
    Ghosh, Joydeep
    Munugalavadla, Veerendra
    Hanneman, Philip
    Beane, Joal D.
    Kapur, Reuben
    [J]. BLOOD, 2012, 119 (17) : 3951 - 3961
  • [7] p85α regulatory subunit of class IA PI-3Kinase regulates osteoclast function(s) and bone mass.
    Munugalavadla, V
    Sims, E
    Ingram, DA
    Robling, A
    Kapur, R
    [J]. BLOOD, 2005, 106 (11) : 627A - 627A
  • [8] The p85α regulatory subunit of class IA phosphoinositide 3-kinase regulates β-selection in thymocyte development
    Shiroki, Fumiko
    Matsuda, Satoshi
    Doi, Tomomitsu
    Fujiwara, Mari
    Mochizuki, Yoshito
    Kadowaki, Takashi
    Suzuki, Harumi
    Koyasu, Shigeo
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (03): : 1349 - 1356
  • [9] Genetic and pharmacologic evidence implicating the p85-alphs, but not p85-beta, regulatory subunit of PI-3kinase and Rac2 GTPase in regulating oncogenic KIT induced transformation in acute myeloid leukemia and systemic mastocytosis
    Munugalavadla, V.
    Sims, E. C.
    Kapur, R.
    [J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (09) : 75 - 75
  • [10] p85α subunit of class IA PI-3Kinase plays an essential role in regulating growth and actin based functions in macrophages.
    Munugalavadla, V
    Ingram, DA
    Kapur, R
    [J]. BLOOD, 2003, 102 (11) : 44B - 44B
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