Pubertal status of children with congenital heart disease

被引:1
|
作者
Ghaemmaghami, Zahra [1 ]
Khajali, Zahra [2 ,3 ]
Dalili, Mohammad [4 ,5 ]
Fotovati, Zahra [6 ]
Moradian, Maryam [4 ,5 ]
Sheikhfathollahi, Mahmood [7 ]
机构
[1] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Dept Cardiol, Tehran, Iran
[2] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Dept Adult Cardiol, Tehran, Iran
[3] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Adult Congenital Heart Dis, Tehran, Iran
[4] Iran Univ Med Sci, Dept Pediat Cardiol, Tehran, Iran
[5] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran
[6] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Dept Pediat Cardiol, Valiasr Ave, Tehran 1995614331, Iran
[7] Iran Univ Med Sci, Biostat, Dept Res, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran
关键词
Congenital heart disease; puberty delayed; puberty; growth; MANAGEMENT; FAILURE; PATTERN;
D O I
10.1017/S1047951121002651
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: CHD influences many aspects of life in affected individuals. Puberty, a major aspect of development, is a concern for patients and families. Objectives: We investigated pubertal status in children and adolescents with CHD. Methods: Patients with CHD aged 6-18 were enrolled. Cardiac diagnoses were confirmed using history, examination, and paraclinical tools including echocardiography. An endocrinologist determined pubertal stages, and the second Tanner stages for pubarche (P2), thelarche (B2), and gonadarche (G2) were considered as the pubertal onset. A study with a large sample size on pubertal onset in a normal population was used for comparison. Results: Totally, 451 patients (228 girls and 223 boys) at a median (10th-90th percentile) age of 10.79 (8.02-14.28) years for the girls and 10.72 (8.05-14.03) years for the boys were enrolled. The median (10th-90th percentile) ages at B2 and P2 in the girls with CHD were 10.77 (9.55-12.68) and 10.53 (9.39-12.28) years, respectively, which were higher than the median ages of 9.74 (8.23-11.94) and 10.49 (8.86-12.17) years in the normal girls. The median (10th-90th percentile) ages at G2 and P2 in the boys with CHD were 11.04 (8.85-13.23) and 11.88 (9.78-13.46) years, correspondingly, which were higher than the median ages of 9.01 (6.00-11.84) and 10.34 (6.84-13.10) years in the normal boys. Conclusions: Pubertal onset could be delayed in children with CHD when compared with the normal population.
引用
收藏
页码:574 / 578
页数:5
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