DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR QUANTIFICATION OF URSOLIC ACID IN SOLID DISPERSIONS

被引：0

作者：

Eloy, Josimar de Oliveira ^{[1
]}

Vargas de Oliveira, Erika Cristina ^{[1
]}

Marotta-Oliveira, Samantha Sant'Anna ^{[1
]}

Saraiva, Juliana ^{[1
]}

Marchetti, Juliana Maldonado ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 05期

关键词：

ursolic acid; quantitative analyses; HPLC; OLEANOLIC ACID;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR QUANTIFICATION OF URSOLIC ACID IN SOLID DISPERSIONS. Ursolic acid is a natural molecule that presents several pharmacological properties. In this work, an analytical method by RP-HPLC has been developed and validated for quantification of this drug in the solid dispersions, using PEG 6000 and Poloxamer 407 as polymers. The method was specific, linear in the range of 1.0-50.0 mu g mL(-1) (r<0.99), precise (CV < 5% for both inter-and intra-assays), accurate (maximum deviation of +/- 13%), and robust to the parameters evaluated. This method has proved to be simple and useful for ursolic acid determination in solid dispersions, enabling its determination in pharmaceutical dosage form.

引用

页码：1036 / 1040

页数：5

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