Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation

被引：9

作者：

Lazaro-Navarro, Juan ^{[1
,2
]}

Pimentel-Gutierrez, Helia Judith ^{[1
,2
]}

Gauert, Anton ^{[1
,2
]}

Hagemann, Anja I. H. ^{[1
]}

Eisenschmid, Jassi ^{[3
,4
]}

Goekbuget, Nicola ^{[2
,4
]}

Vick, Binje ^{[2
,5
]}

Jeremias, Irmela ^{[2
,5
]}

Seyfried, Felix ^{[6
]}

Meyer, Luder Hinrich ^{[6
]}

Debatin, Klaus-Michael ^{[6
]}

Richer, Kathrin ^{[7
]}

Bultman, Miriam ^{[7
]}

Neumann, Martin ^{[2
,7
]}

Hanzelmann, Sonja ^{[2
]}

Serve, Hubert ^{[2
,3
,4
]}

Astrahantseff, Kathy ^{[1
]}

Rieger, Michael A. ^{[2
,3
,4
]}

Eckert, Cornelia ^{[1
,2
]}

Baldus, Claudia D. ^{[2
,7
]}

Bastian, Lorenz ^{[2
,7
]}

机构：

[1] Charit Univ med Berlin, Dept Pediat Oncol Hematol, Berlin, Germany

[2] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[3] Frankfurt Canc Inst, Frankfurt, Germany

[4] Goethe Univ Hosp Frankfurt, Dept Med Hematol Oncol, Frankfurt, Germany

[5] Helmholtz Ctr Munich German Ctr Environm Hlth HMG, Dept Apoptosis Hematopoiet Stem Cells, Munich, Germany

[6] Univ Ulm, Dept Pediat & Adolescent Med, Med Ctr, Ulm, Germany

[7] Univ Med Ctr Schleswig Holstein, Med Dept 2, Hematol Oncol, Campus Kiel, Kiel, Germany

来源：

BLOOD ADVANCES | 2021年 / 5卷 / 24期

关键词：

BCL-2; DEPENDENCE; APOPTOSIS; CK2; ACTIVATION; GENOMICS;

D O I：

10.1182/bloodadvances.2021004513

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：5501 / 5506

页数：6

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