Xanthone Natural Products via N-Heterocyclic Carbene Catalysis: Total Synthesis of Atroviridin

被引：26
|
作者：
Suzuki, Yumiko [1 ]
Fukuta, Yoshinori [1 ]
Ota, Shinya [1 ]
Kamiya, Masayo [1 ]
Sato, Masayuki [1 ]
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 10期
关键词：
NUCLEOPHILIC AROYLATION; ACIDIC SPHINGOMYELINASE; IMIDAZOLIDENYL CARBENE; GARCINIA-HANBURYI; ORGANOCATALYSTS; FRUITS; ETHERS;
D O I：
10.1021/jo200303c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of atroviridin has been accomplished by a linear route involving the N-heterocyclic carbene (NHC)-catalyzed aroylation of the fluorobenzene derivative, Claisen cyclization of the O-propargylated benzo-phenones, and intramolecular 1,4-addition of the quinone intermediates. The result provides a viable route to xanthone natural products.
引用
收藏
页码：3960 / 3967
页数：8
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