Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

被引：35

作者：

Gibbons, Linda ^{[1
]}

Rollinson, Sara ^{[1
]}

Thompson, Jennifer C. ^{[1
,2
]}

Robinson, Andrew ^{[1
]}

Davidson, Yvonne S. ^{[1
]}

Richardson, Anna ^{[1
,2
]}

Neary, David ^{[1
,2
]}

Pickering-Brown, Stuart M. ^{[1
]}

Snowden, Julie S. ^{[1
,2
]}

Mann, David M. A. ^{[1
,2
]}

机构：

[1] Univ Manchester, Inst Brain Behav & Mental Hlth, Fac Human & Med Sci, Manchester, Lancs, England

[2] Salford Royal Fdn Trust, Greater Manchester Neurosci Ctr, Dept Neurol, Cerebral Funct Unit, Salford M6 8HD, Lancs, England

来源：

NEUROBIOLOGY OF AGING | 2015年 / 36卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Frontotemporal Lobar degeneration; Progranulin; Interleukin-6; Biomarkers; DEMENTIA; MUTATIONS; DISEASE;

D O I：

10.1016/j.neurobiolaging.2014.10.023

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：1603.e1 / 1603.e4

页数：4

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