Changes in platelet parameters and secondary brain injury in acute craniocerebral trauma

被引：0

作者：

Tang, Xiaoping ^{[1
]}

You, Chao ^{[1
]}

Peng, Hua ^{[2
]}

Zhang, Tao ^{[2
]}

Tang, Wenguo ^{[2
]}

Qi, Jian ^{[2
]}

Luo, Renguo ^{[2
]}

Wang, Yuanchuan ^{[2
]}

Feng, Ling ^{[2
]}

Gou, Zhangyang ^{[2
]}

Duan, Junwei ^{[2
]}

Li, Shun ^{[2
]}

机构：

[1] Sichuan Univ, W China Hosp, Dept Neurosurg, Chengdu 610041, Sichuan Prov, Peoples R China

[2] N Sichuan Med Coll, Affiliated Hosp, Dept Neurosurg, Nanchong 637000, Sichuan Prov, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 20期

关键词：

craniocerebral trauma; platelet; mean platelet volume; platelet distribution width; secondary brain injury; RATS;

D O I：

10.3969/j.issn.1673-5374.2011.20.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Changes in platelet parameters are important in secondary brain injury in acute craniocerebral trauma. We selected 163 patients with craniocerebral trauma who were admitted within 24 hours with nonoperative therapy. Platelet parameters of 40 healthy subjects served as controls. Platelet number was decreased, while mean platelet volume and platelet distribution width values were increased, at 1 and 3 days after injury. Platelet number was lower and mean platelet volume and platelet distribution width were larger in patients with traumatic cerebral infarction and those in Glasgow Coma Scale score < 8 group. Platelet number was negatively correlated to volume of cerebral edema, but positively correlated to Glasgow Outcome Scale score. These data indicate that changes in platelet parameters may be utilized to indicate the state of central nervous system injury and patient prognosis.

引用

页码：1543 / 1547

页数：5

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