Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

被引：16

作者：

Malek-Khatabi, Atefeh ^{[1
]}

Tabandeh, Zahra ^{[2
]}

Nouri, Akram ^{[3
]}

Mozayan, Elaheh ^{[4
]}

Sartorius, Rossella ^{[5
]}

Rahimi, Shahnaz ^{[3
]}

Jamaledin, Rezvan ^{[6
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Biomat, Tehran 1417614411, Iran

[2] Univ Kashan, Fac Chem, Dept Phys Chem, Kashan 8731753153, Iran

[3] Univ Tehran, Coll Sci, Sch Chem, Tehran 141556455, Iran

[4] Univ Kashan, Dept Cell & Mol Biol, Kashan 8731753153, Iran

[5] Inst Biochem & Cell Biol IBBC, I-80131 Naples, Italy

[6] Univ Naples Federico II, Dept Chem Mat & Ind Prod Engn, I-80125 Naples, Italy

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 11期

关键词：

hydrogel; microneedle; biodegradable; microparticles; vaccine; BETA-GLUCAN PARTICLES; CHITOSAN NANOPARTICLES; SUSTAINED-RELEASE; IN-VIVO; INTRADERMAL DELIVERY; SUBUNIT VACCINES; INFLUENZA-VIRUS; HYDROGEL PATCH; MICRONEEDLES; ADJUVANT;

D O I：

10.1021/acsabm.2c00638

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess negligible toxicity. In addition, biomaterial-based vaccines possess adjuvant properties, thereby enhancing immune responses. This Review introduces the use of different biodegradable polymers and their degradation mechanism. Different kinds of vaccines, as well as the interaction between the carriers with the immune system, then are highlighted. Natural and synthetic biodegradable micro-/nanoplatforms, hydrogels, and scaffolds for local or targeted and controlled vaccine release are subsequently discussed.

引用

页码：5015 / 5040

页数：26

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