Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients

被引：26

作者：

Lim, WH

Mathew, TH

Cooper, JE

Bowden, S

Russ, GR

机构：

[1] Queen Elizabeth Hosp, Renal Unit, Woodville, SA 5011, Australia

[2] Queen Elizabeth Hosp, Dept Pathol, Woodville, SA 5011, Australia

[3] Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia

来源：

NEPHROLOGY | 2003年 / 8卷 / 06期

关键词：

cidofovir; polyomavirus BK viral nephropathy; renal allograft;

D O I：

10.1111/j.1440-1797.2008.00214.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Polyomavirus BK viral allograft nephropathy is a potentially reversible cause of deteriorating function of kidney allografts. Initial treatment involves reducing immunosuppressive medications, with low-dose cidofovir an effective alternative in refractory cases. We describe two cases of BK viral allograft nephropathy responding to low-dose cidofovir after a reduction in immunosuppressive medications failed to clear the virus or stabilize the deterioration in renal function. There were no significant side-effects from this treatment in either patient.

引用

页码：318 / 323

页数：6

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