Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients

被引：26

作者：

Lim, WH

Mathew, TH

Cooper, JE

Bowden, S

Russ, GR

机构：

[1] Queen Elizabeth Hosp, Renal Unit, Woodville, SA 5011, Australia

[2] Queen Elizabeth Hosp, Dept Pathol, Woodville, SA 5011, Australia

[3] Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia

来源：

NEPHROLOGY | 2003年 / 8卷 / 06期

关键词：

cidofovir; polyomavirus BK viral nephropathy; renal allograft;

D O I：

10.1111/j.1440-1797.2008.00214.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Polyomavirus BK viral allograft nephropathy is a potentially reversible cause of deteriorating function of kidney allografts. Initial treatment involves reducing immunosuppressive medications, with low-dose cidofovir an effective alternative in refractory cases. We describe two cases of BK viral allograft nephropathy responding to low-dose cidofovir after a reduction in immunosuppressive medications failed to clear the virus or stabilize the deterioration in renal function. There were no significant side-effects from this treatment in either patient.

引用

页码：318 / 323

页数：6

共 50 条

[1] Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy.
Nickeleit, V
Klimkait, T
Binet, IF
Dalquen, P
Del Zenero, V
Thiel, G
Mihatsch, MJ
Hirsch, HH
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (18): : 1309 - 1315
[2] POLYOMAVIRUS BK VIRUS VIREMIA, BUT NOT THE INDIVIDUAL PLASMA VIRAL LOAD, IS SUGGESTIVE FOR BK NEPHROPATHY IN RENAL TRANSPLANT RECIPIENTS
Schieren, G.
Klossowski, N.
Vonend, O.
Adams, O.
Rump, C.
[J]. TRANSPLANT INTERNATIONAL, 2010, 23 : 30 - 30
[3] Polyomavirus nephropathy caused by JCV in renal allograft recipients
De Marchi, S.
Zuliani, E.
Cereghetti, C.
Gaspert, A.
Fehr, T.
Schonholzer, C.
[J]. SWISS MEDICAL WEEKLY, 2013, 143 : 14S - 14S
[4] Polyomavirus nephropathy and Cytomegalovirus nephritis in renal allograft recipients
Agrawal, Vinita
Gupta, Ramesh Kumar
Jain, Manoj
Prasad, Narayan
Sharma, Raj Kumar
[J]. INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2010, 53 (04) : 672 - 675
[5] Risk factors for BK polyomavirus nephritis in renal allograft recipients
Rocha, PN
Plumb, TJ
Miller, SE
Howell, DN
Smith, SR
[J]. CLINICAL TRANSPLANTATION, 2004, 18 (04) : 456 - 462
[6] THE HEALTH BENEFITS AND COSTS OF CIDOFOVIR FOR THE TREATMENT OF POLYOMAVIRUS (BK) NEPHROPATHY IN RECIPIENTS OF KIDNEY TRANSPLANTS
Danny, Hua
Kirsten, Howard
Jonathan, Craig
Germaine, Wong
[J]. IMMUNOLOGY AND CELL BIOLOGY, 2011, 89 (07): : A23 - A23
[7] Treatment of BK Polyomavirus-Associated Nephropathy in Paediatric Kidney Transplant Recipients: Leflunomide Versus Cidofovir
Aksoy, Guelsah Kaya
Erkan, Mine
Koyun, Mustafa
Comak, Elif
Toru, Havva Serap
Mutlu, Derya
Akkaya, Bahar
Akman, Sema
[J]. EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2024, 22 (01) : 29 - 34
[8] Quantification of BK Viral Load in Asymptomatic Renal Allograft Recipients
Chan, Gary C. W.
Leung, Anskar Y. H.
Wong, Anders S. Y.
Chan, Kwok Wah
Kwong, Yok Lam
Lai, Kar Neng
Tang, Sydney C. W.
[J]. RENAL FAILURE, 2012, 34 (05) : 550 - 554
[9] HUMAN POLYOMAVIRUS (BK) INFECTION AND URETERIC STENOSIS IN RENAL-ALLOGRAFT RECIPIENTS
COLEMAN, DV
MACKENZIE, EFD
GARDNER, SD
POULDING, JM
AMER, B
RUSSELL, WJI
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1978, 31 (04) : 338 - 347
[10] Consensus Definitions of BK Polyomavirus Nephropathy in Renal Transplant Recipients for Clinical Trials
Imlay, Hannah
Baum, Paul
Brennan, Daniel C.
Hanson, Kimberly E.
Hodges, Michael R.
Hodowanec, Aimee C.
Komatsu, Takashi E.
Ljungman, Per
Miller, Veronica
Natori, Yoichiro
Nickeleit, Volker
O'Rear, Jules
Pikis, Andreas
Randhawa, Parmjeet S.
Sawinski, Deirdre
Singh, Harsharan K.
Westman, Gabriel
Limaye, Ajit P.
[J]. CLINICAL INFECTIOUS DISEASES, 2022, 75 (07) : 1210 - 1216

← 1 2 3 4 5 →