An Exploratory Study of the Safety and Efficacy of a Trigonella foenum-graecum Seed Extract in Early Glucose Dysregulation: A Double-Blind Randomized Placebo-Controlled Trial

被引:7
|
作者
Pickering, Emily [1 ,2 ]
Steels, Elizabeth [1 ,2 ]
Rao, Amanda [3 ]
Steadman, Kathryn J. [1 ]
机构
[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4102, Australia
[2] Evidence Sci Pty Ltd, Brisbane, Qld 4005, Australia
[3] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld 4102, Australia
关键词
Trigonella foenum-graecum; fenugreek; prediabetes; type; 2; diabetes; fasting blood glucose; post-prandial glucose; insulin; FENUGREEK SEEDS; INSULIN-RESISTANCE; BLOOD-GLUCOSE; TYPE-2; L; 4-HYDROXYISOLEUCINE; HYPERGLYCEMIA; STRESS;
D O I
10.3390/pharmaceutics14112453
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: This was an exploratory study to assess the safety and efficacy of a specialized Trigonella foenum-graceum L. seed extract for supporting healthy blood glucose metabolism in a pre-diabetic cohort. Methods: Fifty-four participants were randomised to receive 500 mg/day of T. foenum-graecum seed extract or matching placebo daily for 12 weeks. Fasting blood glucose (FBG), post-prandial glucose (PPBG), HbA1c, fasting insulin (FI), post-prandial insulin (PPI) and C-peptide were assessed at baseline, week 6 and week 12. Lipid levels, liver enzymes and C-reactive protein (CRP), along with safety markers and tolerability were also assessed at baseline and week 12. Results: By week 12 there was a significant difference in FBG (p < 0.001), PPBG (p = 0.007) and triglycerides (p = 0.030) between treatment groups, with no changes in HbA1c (p = 0.41), FI (p = 0.12), PPI (p = 0.50) or C-peptide (p = 0.80). There was no difference in total cholesterol (p = 0.99), high-density lipoprotein (p = 0.35), low density lipoprotein (p = 0.60) or CRP (p = 0.79). There was no change in safety markers and the treatment was well tolerated. Conclusions: The results of the study indicated that T. foenum-graecum seed extract may influence blood glucose metabolism and larger studies are warranted to evaluate efficacy and potential mechanisms of action.
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页数:13
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