Real-time protein binding detection with neuromorphic integrated sensor

被引：0
|
作者：
Jacquot, Blake C. [1 ]
Munoz, N. L. [1 ]
Branch, D. W. [2 ]
Kan, E. C. [1 ]
机构：
[1] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA
[2] Sandia Natl Labs, Albuquerque, NM 87185 USA
来源：
2007 IEEE SENSORS, VOLS 1-3 | 2007年
关键词：
protein microarray; biosensor; FET; floating-gate; chemical sensor;
D O I：
10.1109/ICSENS.2007.4388490
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
Real time protein binding interactions between biotinylated bovine serum albumen (BSA) and streptavidin (SA) are detected using chemoreceptive neuron MOS (CvMOS) transistors with extended floating gate structures. This enables protein interaction events to be monitored by a sensing gate area that is only capacitively coupled to the sensing circuits and far removed from the active area, reducing the invasiveness without loss of sensitivity. The use of both sensing and control gates to control the floating gate potential eliminates the need of an analyte reference electrode.
引用
收藏
页码：678 / 681
页数：4
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