The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence

被引：5
|
作者：
Priya, S. K. Sujitha [1 ]
Jha, Ankita [1 ]
Satish Kumar, Rajappan Chandra [2 ]
Sabarathinam, Sarvesh [2 ]
机构：
[1] SRM Inst Sci & Technol, Dept Pharm Practice, Kancheepuram 603203, Tamil Nadu, India
[2] SRM Inst Sci & Technol, Interdisciplinary Inst Indian Syst Med IIISM, Drug Testing Lab, Kattankulathur 603203, Tamil Nadu, India
来源：
FUTURE SCIENCE OA | 2022年 / 8卷 / 06期
关键词：
bioactive compounds; cytokines; dextran sodium sulfate; guggulsterone; inflammatory bowel disease; intestinal epithelial cells; NF-kappa B; preclinical studies; ulcerative colitis; INTESTINAL EPITHELIAL-CELLS; CYTOKINES; COLITIS;
D O I：
10.2144/fsoa-2022-0020
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-kappa B, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.
引用
收藏
页数：5
相关论文
共 50 条
  • [31] RETRACTED: miRNA-129/FBW7/NF-κB, a Novel Regulatory Pathway in Inflammatory Bowel Disease (Retracted Article)
    Meng, Qinghui
    Wu, Weihua
    Pei, Tiemin
    Xue, Junlin
    Xiao, Peng
    Sun, Liang
    Li, Long
    Lang, Desen
    MOLECULAR THERAPY NUCLEIC ACIDS, 2020, 19 : 731 - 740
  • [32] NF-κB signaling proteins as therapeutic targets for inflammatory bowel diseases
    Jobin, C
    Sartor, RB
    INFLAMMATORY BOWEL DISEASES, 2000, 6 (03) : 206 - 213
  • [33] Study on the Role of Salivary Flora and NF-κB Inflammatory Signal Pathway in Oral Lichen Planus
    Deng, Songsong
    Xu, Yingjie
    Wang, Xinxin
    Liu, Mengjia
    Li, Lulu
    Yu, Xixi
    Wang, Yiheng
    Wu, Yingtao
    Wang, Wanchun
    Gao, Meihua
    Cong, Beibei
    INFLAMMATION, 2020, 43 (03) : 994 - 1008
  • [34] Study on the Role of Salivary Flora and NF-κB Inflammatory Signal Pathway in Oral Lichen Planus
    Songsong Deng
    Yingjie Xu
    Xinxin Wang
    Mengjia Liu
    Lulu Li
    Xixi Yu
    Yiheng Wang
    Yingtao Wu
    Wanchun Wang
    Meihua Gao
    Beibei Cong
    Inflammation, 2020, 43 : 994 - 1008
  • [35] Prophylactic vs. Therapeutic Effect of Probiotics on the Inflammation Mediated by the NF-κB Pathway in Inflammatory Bowel Conditions
    Najafi, Saeideh
    Sotoodehnejadnematalahi, Fattah
    Amiri, Mohammad Mehdi
    Pourshafie, Mohammad Reza
    Rohani, Mahdi
    BIOMEDICINES, 2023, 11 (06)
  • [36] Inflammatory dyskinesis: defects of NF-κB dynamic behaviour as a new potential biomarker for personalized medicine in inflammatory bowel disease
    Sellge, G.
    Papoutsopoulou, S.
    Verdier, J.
    Trautwein, C.
    Bergey, F.
    Burkitt, M.
    Sheibani, R.
    Pierik, M.
    Jonkers, D.
    White, M.
    Paszek, P.
    dos Santos, V. Martins
    Rosenstiel, P.
    Mueller, W.
    Probert, C.
    JOURNAL OF CROHNS & COLITIS, 2017, 11 : S55 - S56
  • [37] Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients
    Papoutsopoulou, Stamatia
    Burkitt, Michael D.
    Bergey, Francois
    England, Hazel
    Hough, Rachael
    Schmidt, Lorraine
    Spiller, David G.
    White, Michael H. R.
    Paszek, Pawel
    Jackson, Dean A.
    Dos Santos, Vitor A. P. Martins
    Sellge, Gernot
    Pritchard, D. Mark
    Campbell, Barry J.
    Mueller, Werner
    Probert, Chris S.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [38] Abnormal activation of transcription factor NF-κB involved in steroid resistance in chronic inflammatory bowel disease
    Bantel, H
    Domschke, W
    Schulze-Osthoff, K
    Kaskas, B
    Gregor, M
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (07): : 1845 - 1846
  • [39] Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
    Nirvanappa, Anilkumar C.
    Mohan, Chakrabhavi Dhananjaya
    Rangappa, Shobith
    Ananda, Hanumappa
    Sukhorukov, Alexey Yu
    Shanmugam, Muthu K.
    Sundaram, Mahalingam S.
    Nayaka, Siddaiah Chandra
    Girish, Kesturu S.
    Chinnathambi, Arunachalam
    Zayed, M. E.
    Alharbi, Sulaiman Ali
    Sethi, Gautam
    Basappa
    Rangappa, Kanchugarakoppal S.
    PLOS ONE, 2016, 11 (09):
  • [40] CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
    Xu, Zhaohui
    Liu, Ruitao
    Huang, Ling
    Xu, Yuxin
    Su, Mingmin
    Chen, Jiayu
    Geng, Lanlan
    Xu, Wanfu
    Gong, Sitang
    BIOMED RESEARCH INTERNATIONAL, 2020, 2020
12345