Structural genomics and drug discovery

被引：61
|
作者：
Lundstrom, K. [1 ]
机构：
[1] Flamel Technol, F-69693 Venissieux, France
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 02期
关键词：
structural genomics; drug discovery; structure-based drug design; recombinant protein expression; protein purification; structure determination; X-ray crystallography; nuclear magnetic resonance; electron microscopy;
D O I：
10.1111/j.1582-4934.2007.00028.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Structure determination has already proven useful for lead optimization and direct drug design. The number of high-resolution structures available in public databases today exceeds 30,000 and will definitely aid in structure-based drug design. Structural genomics approaches covering whole genomes, topologically similar proteins or gene families are great assets for further progress in the development of new drugs. However, membrane proteins representing 70% of current drug targets are poorly characterized structurally. The problems have been related to difficulties in obtaining large amount of recombinant membrane proteins as well as their purification and structure determination. Structural genomics has proven successful in developing new methods in areas from expression to structure determination by studying a large number of target proteins in parallel.
引用
收藏
页码：224 / 238
页数：15
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