Further novel milbemycin antibiotics from Streptomyces sp E225 fermentation, isolation and structure elucidation

被引：9

作者：

Baker, GH

Blanchflower, SE

Dorgan, RJJ

Everett, JR

Manager, BR

Reading, CR

Readshaw, SA

Shelley, P

机构：

[1] SMITHKLINE BEECHAM ANIM HLTH,TADWORTH KT20 7NT,SURREY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DIV RES,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

[3] SMITHKLINE BEECHAM PHARMACEUT,DIV RES,EPSOM T18 5XQ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 03期

关键词：

D O I：

10.7164/antibiotics.49.272

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VR148642 which contains a furan ring at the terminus of the C-26 side chain. Several of these new compounds were shown to possess potent anthelmintic activity. An analysis of NMR chemical shift trends in this series of metabolites is presented.

引用

页码：272 / 280

页数：9

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