Mammalian sex determination: joining pieces of the genetic puzzle

被引：0
|
作者：
Jimenez, R [1 ]
Burgos, M [1 ]
机构：
[1] Univ Granada, Fac Ciencias, Dept Genet, E-18071 Granada, Spain
来源：
BIOESSAYS | 1998年 / 20卷 / 09期
关键词：
D O I：
10.1002/(SICI)1521-1878(199809)20:9<696::AID-BIES2>3.0.CO;2-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian sex determination is controlled by the Y-linked gene SRY. Studies of sex-reversed patients and experimental data obtained with mice have identified other genes, such as DAX1, SOX9, SF1, and WT1, which take part in the process, and have suggested how these genes interact to determine the sex of a mammalian embryo, A recent paper in Nature by Swain et al.((1)) provides experimental data that basically confirm the previously proposed hypothesis((2)) that SRY acts by inhibiting the action of DSS/DAX1, which is a repressor of genes of the male pathway. BioEssays 20:696-699, 1998. (C) 1998 John Wiley & Sons, Inc.
引用
收藏
页码：696 / 699
页数：4
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