Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents

被引：27
|
作者：
Villani, Claudio
Laleu, Benoit
Mobian, Piene
Lacour, Jerome
机构：
[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Sostanze Bioloagicamen, I-00185 Rome, Italy
[2] Univ Geneva, Dept Chim Organ, CH-1211 Geneva, Switzerland
来源：
CHIRALITY | 2007年 / 19卷 / 08期
关键词：
helicenes; enantiomers; cellulose carbamate; teicoplanin aglycon; circular dichroism detection;
D O I：
10.1002/chir.20345
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[4]Heterohelicenium cations la-c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations la-c have been resolved by HPLC using water-based eluents containing KPF6 as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte: structure on retention and enantioselectivity was investigated.
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页码：601 / 606
页数：6
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