Preparation of Irisquinone Hydroxypropyl-β-Cyclodextrin Inclusion Complex and its thermodynamic stability

被引：0
|
作者：
Zhang, Xue-Nong [1 ]
Gong, Jin-Hong [1 ]
Tang, Li-Hua [1 ]
Zhang, Qiang
机构：
[1] Soochow Univ, Coll Pharm, Suzhou 215123, Peoples R China
来源：
2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11 | 2009年
关键词：
Irisquinone; Inclusion complex; Identification; Apparent solubility; DRUGS; CHINA;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The inclusion complex formation of irisquinone with hydroxypropyl-beta-cyclodextrin(HP-beta-CD) and the physicochemical properties were studied. Complex of host molecules with irisquinoe was studied by x-ray diffraction (XRD) and differential scanning calorimetry(DSC). The quantitative analysis with uv-vis indicated that HP-beta-CD could increase the solubility of irisquinone, where the best results was given with HP-beta-CD :irisquinone 2:1 molar ratio. The binding constants of inclusion complex formulation were obtained with relative Higuchi Principle and thermodynamics
引用
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页码：3219 / +
页数：2
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