Use of Antiepileptic Drugs in Patients with Chronic Kidney Disease and End Stage Renal Disease

被引：24

作者：

Bansal, Amar D. ^{[1
]}

Hill, Chloe E. ^{[2
]}

Berns, Jeffrey S. ^{[1
]}

机构：

[1] Univ Penn, Renal Electrolyte & Hypertens Div, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

SEMINARS IN DIALYSIS | 2015年 / 28卷 / 04期

关键词：

GRANULOMATOUS INTERSTITIAL NEPHRITIS; ANTIDIURETIC-HORMONE SECRETION; HIGH-FLUX HEMODIALYSIS; PROTEIN-BINDING; PERITONEAL-DIALYSIS; PHARMACOKINETICS; CARBAMAZEPINE; LAMOTRIGINE; TOPIRAMATE; GABAPENTIN;

D O I：

10.1111/sdi.12385

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Epilepsy is a disorder with an approximate worldwide prevalence of 1%. Due to complexities of metabolism, protein-binding, renal elimination, and other pharmacokinetic parameters, the dosing of antiepileptic drugs (AEDs) in patients with chronic kidney disease (CKD) or end stage renal disease (ESRD) deserves special attention. This is a review of the most commonly prescribed AEDs with special focus on their indication, pharmacokinetics, and unique considerations for use in patients with CKD and ESRD. A review of their renal toxicities is also included.

引用

页码：404 / 412

页数：9

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