Rational molecular design and EPC synthesis of a type VI β-turn inducing peptide mimetic

被引：0
|
作者：
Hoffmann, T
Lanig, H
Waibel, R
Gmeiner, P
机构：
[1] Univ Erlangen Nurnberg, Comp Chem Ctr, D-91052 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Dept Med Chem, Emil Fischer Ctr, D-91052 Erlangen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 18期
关键词：
D O I：
10.1002/1521-3773(20010917)40:18<3361::AID-ANIE3361>3.0.CO;2-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A fruitful combination of molecular dynamics based design and modern synthetic reactions led to a conformatively rigidized cis-peptidyl proline surrogate (see picture). NMR spectroscopic experiments clearly show the existance of type VIa β-turn properties that are of interest in drug discovery.
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页码：3361 / +
页数：5
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