Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole- and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids

被引：73
|
作者：
Butera, JA
Antane, SA
Hirth, B
Lennox, JR
Sheldon, JH
Norton, NW
Warga, D
Argentieri, TM
机构：
[1] Wyeth Ayerst Res, Med Chem Chem Sci, Princeton, NJ 08543 USA
[2] Wyeth Ayerst Res, Urol Res, Womens Hlth Discovery Res, Radnor, PA 19087 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(01)00385-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Compounds in a structurally novel series of substituted 10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acids and related 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids were prepared and shown to possess potent, bladder-selective smooth muscle relaxant properties and thus are potentially useful for the treatment of urge urinary incontinence. Electrophysiological studies using rat detrusor myocytes have demonstrated that prototype compound 7 produces a significant increase in hyperpolarizing current, which is iberiotoxin (IbTx)-reversed, thus consistent with activation of the large-conductance Ca2+-activated potassium channel (BKCa). (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2093 / 2097
页数：5
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