Platelet activation, epinephrine, and blood pressure in obstructive sleep apnea syndrome

被引：121

作者：

Eisensehr, I

Ehrenberg, BL

Noachtar, S

Korbett, K

Byrne, A

McAuley, A

Palabrica, T

机构：

[1] Univ Munich, Dept Neurol, D-81377 Munich, Germany

[2] Tufts Univ, Dept Neurol, Boston, MA 02111 USA

[3] Tufts Univ, Clin Studies Unit, Boston, MA 02111 USA

[4] Tufts Univ, Pediat Hematol Res Lab, Boston, MA 02111 USA

[5] Tufts Univ, Dept Cardiol, Boston, MA 02111 USA

来源：

NEUROLOGY | 1998年 / 51卷 / 01期

关键词：

D O I：

10.1212/WNL.51.1.188

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: There is an increased risk of patients with obstructive sleep apnea syndrome (OSAS) to have stroke or cardiac infarcts. Besides hypertension, epinephrine-induced platelet activation could be a further reason for the increased cardiovascular morbidity and mortality in OSAS. Methods: During a 4-month period (August 1994 to December 1994) we recruited prospectively 76 patients referred for polysomnograms because of a suspected sleep disorder such as OSAS. Results: Fifty patients had no respiratory events during sleep (non-OSAS), 19 patients had more than five but less than 50 obstructive apneas or hypopneas per hour of total sleep time (mild-to-moderate OSAS group), and seven patients had an apnea hypopnea index of more than 50 per hour of total sleep time (severe OSAS group). Blood pressure, plasma epinephrine levels, and P-selectin expression (as a marker for platelet activation) were measured in every patient at 9 PM and 6 AM (before and after the polysomnogram). There was a significant correlation of the apnea hypopnea index with 9 PM and 6 AM systolic and diastolic blood pressure, with 9 Pbl platelet activation, and with 6 AM epinephrine levels mainly due to high values in the severe OSAS group. Conclusions: Our results suggest that platelet activation, epinephrine, and high blood pressure play a role in the high prevalence of cerebrovascular and cardiovascular events in patients with OSAS.

引用

页码：188 / 195

页数：8

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