Formal total synthesis of (+)-didemniserinolipid B

被引：14
|
作者：
Prasad, Kavirayani R. [1 ]
Gandi, Vasudeva Rao [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 23期
关键词：
STEREOSELECTIVE TOTAL-SYNTHESIS; ACID;
D O I：
10.1016/j.tetasy.2010.11.006
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The formal total synthesis of (+)-didemniserinolipid B, a marine tunicate possessing a 6,8-dioxabicyclo[3.2.1]octane framework, was accomplished starting from L-(+)-tartaric acid. The key transformations in the synthesis include the elaboration of a gamma-hydroxy-amide readily obtained by desymmetrization of tartaric acid bis-amide via the controlled addition of a Grignard reagent followed by stereoselective reduction of the resulting ketone. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2848 / 2852
页数：5
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