Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

被引：9
|
作者：
Hu, Yalin [1 ]
Wang, Junling [1 ]
Zhang, Huiyun [1 ]
Xie, Hua [2 ]
Song, Weiwei [2 ]
Jiang, Qijun [3 ]
Zhao, Nan [1 ]
He, Shaoheng [1 ]
机构：
[1] Jinzhou Med Univ, Allergy & Clin Immunol Res Ctr, Affiliated Hosp 1, Jinzhou 121001, Liaoning, Peoples R China
[2] Gen Hosp Shenyang Mil Area Command, PLA Ctr Resp & Allerg Dis Diagnosing Management, Shenyang 110840, Liaoning, Peoples R China
[3] Donggang Ctr Hosp, Dept Dermatol, Donggang 118300, Liaoning, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
BINDING-PROTEIN; HISTAMINE-RELEASE; INTERLEUKIN-18; SKIN; ACTIVATION; MODULATION; CHILDREN; SERUM; INHIBITORS; INDUCTION;
D O I：
10.1155/2017/3090782
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
IL-18 receptor (R) in eczema. We therefore investigated the expression of IL-18, IL-18BP, and IL-18R on mast cells by using flow cytometry analysis and mouse eczema model. The results showed that plasma free IL-18 and free IL-18BP levels in eczema patients were higher than those in healthy controls. IL-18 provoked up to 3.1-fold increase in skin mast cells. IL-18 induced also an increase in IL-18BP+ mast cells, but a reduction of IL-18R+ mast cells in mouse eczema skin. It was found that house dust mite allergen Der p1 and egg allergen OVA induced upregulation of the expression of IL-18, IL-18BP, and IL-18R mRNAs in HMC-1 cells following 2 and 16 h incubation. In conclusion, correlation of IL-18 and IL-18BP in eczema plasma suggests an important balance between IL-18 and IL-18BP in eczema. The decrease in molar concentration ratio of plasma IL-18BP/IL-18 and allergen-induced upregulated expression of IL-18 and IL-18R in skin mast cells of the patients with eczema suggests that anti-IL-18 including IL-18BP therapy may be useful for the treatment of eczema.
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页数：12
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