Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in children

被引:20
|
作者
Ishino, K
Weng, YG
AlexiMeskishvili, V
Loebe, M
Uhlemann, F
Lange, PE
Hetzer, R
机构
[1] GERMAN HEART INST,DEPT THORAC & CARDIOVASC SURG,BERLIN,GERMANY
[2] GERMAN HEART INST,DEPT PEDIAT CARDIOL,BERLIN,GERMANY
关键词
extracorporeal membrane oxygenation; bridge; heart transplantation; congenital heart defects; renal failure; centrifugal pump;
D O I
10.1111/j.1525-1594.1996.tb04513.x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The feasibility and efficacy of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation was examined in 6 pediatric patients who suffered irreversible myocardial failure after undergoing surgery for congenital heart defects. The mean time of ECMO support was 260.5 h, range, 101-102 h. Three patients underwent transplantation, 2 of whom are longterm survivors. Progressive hypotension as a result of capillary leak syndrome precluded further ECMO support in the other 3 patients. Overall, 2 of the 6 patients survived. Major complications were encountered in 4 patients including bleeding in 2, a seizure in 1, and renal failure in 3, 2 of whom recovered renal function after transplantation. Infection did not occur in any of the 6 patients. Exchanging ECMO components was performed with no difficulties; these exchanges included a centrifugal pump once for 2 patients and a membrane oxygenator once for 3 patients. Our results indicate that ECMO can safely keep critically ill pediatric transplant candidates alive for more than 1 week with a low incidence of multiple organ failure.
引用
收藏
页码:728 / 732
页数:5
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