The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review

被引：10
|
作者：
Bullert, Amanda J. [1 ,2 ]
Doorn, Jonathan A. [1 ,2 ]
Stevens, Hanna E. [1 ,3 ]
Lehmler, Hans-Joachim [1 ,2 ]
机构：
[1] Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 2021年 / 34卷 / 09期
基金：
美国国家卫生研究院;
关键词：
2-HIT EXPOSURE; RELIABILITY; RATS;
D O I：
10.1021/acs.chemrestox.1c00226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.
引用
收藏
页码：1948 / 1952
页数：5
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