Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives (vol 13, pg 4936, 2005)

被引：2
|
作者：
Hisamichi, H
Naito, R
Toyoshima, A
Kawano, N
Ichikawa, A
Orita, A
Orita, M
Hamada, N
Takeuchi, M
Ohta, M
Tsukamoto, S
机构：
[1] Astellas Pharma Inc, Inst Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
[2] Astellas Pharma Inc, Dept Clin Dev, Tokyo 1748612, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期
关键词：
D O I：
10.1016/j.bmc.2005.08.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：6277 / 6279
页数：3
相关论文
共 50 条
  • [31] Phosphodiesterase inhibitors. Part 6: Design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity
    Kojima, Akihiko
    Takita, Satoshi
    Sumiya, Tatsunobu
    Ochiai, Koji
    Iwase, Kazuhiko
    Kishi, Tetsuya
    Ohinata, Akira
    Yageta, Yuichi
    Yasue, Tokutaro
    Kohno, Yasushi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (19) : 5311 - 5316
  • [32] Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors (vol 11, pg 2397, 2001)
    Aoyama, Y
    Uenaka, M
    Konoike, T
    Iso, Y
    Nishitani, Y
    Kanda, A
    Naya, N
    Nakajima, M
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (15) : 2055 - 2055
  • [33] Structure-activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1 entry inhibitors
    Song, Gaopeng
    Shen, Xintian
    Li, Sumei
    Li, Yibin
    Liu, Yunpeng
    Zheng, Yushan
    Lin, Ruheng
    Fan, Jihong
    Ye, Hanming
    Liu, Shuwen
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 93 : 431 - 442
  • [34] Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships
    Thysiadis, Savvas
    Mpousis, Spyros
    Avramidis, Nicolaos
    Katsamakas, Sotirios
    Balomenos, Athanasios
    Remelli, Rosaria
    Efthimiopoulos, Spyros
    Sarli, Vasiliki
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (05) : 1014 - 1022
  • [35] C17,20-lyase inhibitors.: Part 2:: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
    Matsunaga, N
    Kaku, T
    Ojida, A
    Tanaka, T
    Hara, T
    Yamaoka, M
    Kusaka, M
    Tasaka, A
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (16) : 4313 - 4336
  • [36] Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β
    Saitoh, Morihisa
    Kunitomo, Jun
    Kimura, Eiji
    Hayase, Yoji
    Kobayashi, Hiromi
    Uchiyama, Noriko
    Kawamoto, Tomohiro
    Tanaka, Toshimasa
    Mol, Clifford D.
    Dougan, Douglas R.
    Textor, Garret S.
    Snell, Gyorgy P.
    Itoh, Fumio
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (05) : 2017 - 2029
  • [37] Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants
    Clark, RF
    Wang, SY
    Ma, ZK
    Weitzberg, M
    Motter, C
    Tufano, M
    Wagner, R
    Gu, YG
    Dandliker, PJ
    Lerner, CG
    Chovan, LE
    Cai, YN
    Black-Schaefer, CL
    Lynch, L
    Kalvin, D
    Nilius, AM
    Pratt, SD
    Soni, N
    Zhang, TY
    Zhang, XL
    Beutel, BA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (12) : 3299 - 3302
  • [38] Nucleoside Transport Inhibitors: Structure-Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein
    Saravanan, Kappusamy
    Barlow, Hannah C.
    Barton, Marion
    Calvert, A. Hilary
    Golding, Bernard T.
    Newell, David R.
    Northen, Julian S.
    Curtin, Nicola J.
    Thomas, Huw D.
    Griffin, Roger J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (06) : 1847 - 1859
  • [39] Design, Synthesis, and Structure-Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists
    Wang, Wenli
    Zheng, Lan
    Li, Wei
    Zhu, Chen
    Peng, Weiqing
    Han, Bing
    Fu, Wei
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 60 (01) : 235 - 248
  • [40] Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies (vol 51, pg 1834, 2008)
    Sato, Hiroyuki
    Macchiarulo, Antonio
    Thomas, Charles
    Gioiello, Antimo
    Une, Mizuho
    Hofmann, Alan F.
    Saladin, Regis
    Schoonjans, Kristina
    Pellieciari, Roberto
    Auwerx, Johan
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (15) : 4849 - 4849
12345