Effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons

被引：2
|
作者：
Elmore, Eugene [1 ]
Lao, Xyoan Y. [1 ]
Kapadia, Rubina L. [1 ]
Redpath, J. Leslie [1 ]
机构：
[1] Univ Calif Irvine, Sch Med, Dept Radiat Oncol, Irvine, CA 92697 USA
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2011年 / 87卷 / 06期
关键词：
adaptive response; carcinogenesis; dose-response curve; LOW-LET RADIATION; HUMAN CELL HYBRIDS; ADAPTIVE RESPONSE; HUMAN-LYMPHOCYTES; EXPRESSION; REPAIR; PARTICLES; DAMAGE; IONS;
D O I：
10.3109/09553002.2011.570415
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Purpose: To determine the effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons. Materials and methods: The experimental system used was the human hybrid cell assay. The dose-rates examined were 50 cGy/min and 20 cGy/h. The dose-rate 20 cGy/h was chosen as this is in the range of the maximum dose-rate that can be experienced in an unshielded space environment following a solar flare. At low dose-rate (LDR), doses from 0.5-100 cGy were studied. At high dose rate (HDR), the dose range was 0.5-200 cGy. Results: The data indicated no significant differences between the two dose-rates at doses up to 100 cGy. Conclusion: For the endpoint of neoplastic transformation in vitro, high dose-rate data may be sufficient to estimate low dose-rate effects (20 cGy/h) in the dose range up to 100 cGy from 232 MeV protons. The data are of relevance to risk estimation for space travel.
引用
收藏
页码：622 / 627
页数：6
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