Open chromatin and hypertranscription in embryonic stem cells

被引：13
|
作者：
Turner, Bryan M. [1 ]
机构：
[1] Univ Birmingham, Sch Med, Inst Biomed Res, Birmingham B15 2TT, W Midlands, England
来源：
CELL STEM CELL | 2008年 / 2卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.stem.2008.04.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Efroni et al. (2008) use tiling microarrays to reveal genome-wide hypertranscription in mouse embryonic stem cells (ESCs), including expression of normally silent, noncoding regions. Hypertranscription may reflect the unusual "open" structure of ESC chromatin.
引用
收藏
页码：408 / 410
页数：3
相关论文
共 50 条
  • [31] Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock
    Deschamps, Jacqueline
    Duboule, Denis
    GENES & DEVELOPMENT, 2017, 31 (14) : 1406 - 1416
  • [32] The Trithorax Group Protein Ash2l Is Essential for Pluripotency and Maintaining Open Chromatin in Embryonic Stem Cells
    Wan, Ma
    Liang, Jiancong
    Xiong, Yuanyan
    Shi, Fengtao
    Zhang, Yi
    Lu, Weisi
    He, Quanyuan
    Yang, Dong
    Chen, Rui
    Liu, Dan
    Barton, Michelle
    Zhou Songyang
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (07) : 5039 - 5048
  • [33] 20 years of stemness: From stem cells to hypertranscription and back
    Kim, Yun-Kyo
    Ramalho-Santos, Miguel
    STEM CELL REPORTS, 2025, 20 (03):
  • [34] Parallel gateways to pluripotency: open chromatin in stem cells and development
    Koh, Fong Ming
    Sachs, Michael
    Guzman-Ayala, Marcela
    Ramalho-Santos, Miguel
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2010, 20 (05) : 492 - 499
  • [35] MAD2L2 Promotes Open Chromatin in Embryonic Stem Cells and Derepresses the Dppa3 Locus
    Rahjouei, Ali
    Pirouz, Mehdi
    Di Virgilio, Michela
    Kamin, Dirk
    Kessel, Michael
    STEM CELL REPORTS, 2017, 8 (04): : 813 - 821
  • [36] The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells
    Helle F Jørgensen
    Véronique Azuara
    Shannon Amoils
    Mikhail Spivakov
    Anna Terry
    Tatyana Nesterova
    Bradley S Cobb
    Bernard Ramsahoye
    Matthias Merkenschlager
    Amanda G Fisher
    Genome Biology, 8
  • [37] Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells
    Zheng, Weisheng
    Wang, Liping
    He, Wenteng
    Hu, Xinjie
    Zhu, Qianshu
    Gu, Liang
    Jiang, Cizhong
    CELL PROLIFERATION, 2023, 56 (09)
  • [38] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bernstein, BE
    Mikkelsen, TS
    Xie, XH
    Kamal, M
    Huebert, DJ
    Cuff, J
    Fry, B
    Meissner, A
    Wernig, M
    Plath, K
    Jaenisch, R
    Wagschal, A
    Feil, R
    Schreiber, SL
    Lander, ES
    CELL, 2006, 125 (02) : 315 - 326
  • [39] The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells
    Jorgensen, Helle F.
    Azuara, Veronique
    Amoils, Shannon
    Spivakov, Mikhail
    Terry, Anna
    Nesterova, Tatyana
    Cobb, Bradley S.
    Ramsahoye, Bernard
    Merkenschlager, Matthias
    Fisher, Amanda G.
    GENOME BIOLOGY, 2007, 8 (08)
  • [40] Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells
    Morozumi, Yuichi
    Boussouar, Faycal
    Tan, Minjia
    Chaikuad, Apirat
    Jamshidikia, Mahya
    Colak, Gozde
    He, Huang
    Nie, Litong
    Petosa, Carlo
    de Dieuleveult, Maud
    Curtet, Sandrine
    Vitte, Anne-Laure
    Rabatel, Clothilde
    Debernardi, Alexandra
    Cosset, Francois-Loic
    Verhoeyen, Els
    Emadali, Anouk
    Schweifer, Norbert
    Gianni, Davide
    Gut, Marta
    Guardiola, Philippe
    Rousseaux, Sophie
    Gerard, Matthieu
    Knapp, Stefan
    Zhao, Yingming
    Khochbin, Saadi
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2016, 8 (04) : 349 - 362
12345