DjApi5 is required for homeostasis in planarian Dugesia japonica

被引：0
|
作者：
Liu, Shuo [1 ]
Chen, Meishan [1 ]
Liu, Xi [1 ]
Zheng, Kang [1 ]
Liu, Baohua [3 ]
Wu, Weiwei [1 ]
Pang, Qiuxiang [1 ,2 ]
机构：
[1] Shandong Univ Technol, Sch Life Sci, Antiaging & Regenerat Med Res Inst, Zibo 255049, Peoples R China
[2] Shandong Univ Technol, Sch Life Sci, Lab Dev & Evolutionary Biol, Zibo 255049, Peoples R China
[3] Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 597卷
基金：
中国国家自然科学基金;
关键词：
Planarian; Homeostasis; Regeneration; DjApi5; DjAcinus;
D O I：
10.1016/j.bbrc.2022.01.125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Orchestrated apoptosis in planarian Dugesia japonica is very important for its degrowth and regeneration. Apoptosis Inhibitor-5 (API5) is an anti-apoptotic factor that negatively regulates cell apoptosis. We characterized the conserved structure of DjApi5, however, the biological function of DjApi5 in planarians needs further investigation. In this study, we found that DjApi5 and its interacting molecular DjAcinus are required for planarian homeostasis, which may be correlated with their specific localization in neoblasts in addition to their anti-apoptosis functions. We further demonstrated the increased expression of DjApi5 during planarian regeneration, and DjApi5 deficiency affects normal regeneration processes. These re-sults indicated new functions of DjApi5 in development. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码：140 / 146
页数：7
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