Hb S/β+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region

被引：6

作者：

Amid, Ali ^{[1
]}

Cheong, Melina ^{[1
]}

Eng, Barry ^{[2
]}

Hanna, Meredith ^{[2
]}

Hohenadel, Betty-Ann ^{[2
]}

Nakamura, Lisa M. ^{[2
]}

Walker, Lynda ^{[2
]}

Odame, Isaac ^{[1
]}

Kirby-Allen, Melanie ^{[1
]}

Waye, John S. ^{[2
,3
]}

机构：

[1] Hosp Sick Children, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada

[2] Hamilton Reg Lab Med Program, Hamilton, ON, Canada

[3] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

HAEMATOLOGICA | 2015年 / 100卷 / 05期

关键词：

novel deletion; locus control region; Hb S/beta(+)-thalassemia; DNase I hypersensitive sites; CELL-DISEASE; THALASSEMIA; HETEROZYGOSITY; PHENOTYPE;

D O I：

10.3324/haematol.2014.117408

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 16 条

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[12] Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice
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[13] AUTONOMOUS, ERYTHROID-SPECIFIC DNASE-I HYPERSENSITIVE SITE FORMED BY HUMAN BETA-GLOBIN LOCUS-CONTROL REGION (LCR) 5'-HS-2 IN TRANSGENIC MICE
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[15] Downregulation of human IL4 and IL13 expression by CRISPR/Cas9-mediated deletion of DNase I hypersensitive site HS11/12 from a transgenic human Th2 cytokine locus
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Rosenbaum, David
Pivniouk, Oksana
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JOURNAL OF IMMUNOLOGY, 2016, 196
[16] A NOVEL DELETIONS OF SIMILAR-TO 27-KB INCLUDING THE BETA-GLOBIN GENE AND THE LOCUS-CONTROL REGION 3'HS-1 REGULATORY SEQUENCE - BETA(DEGREES)-THALASSEMIA OR HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN
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