Fine tuning of physico-chemical parameters to optimise a new series of novobiocin analogues

被引：27
|
作者：
Schio, L
Chatreaux, F
Loyau, V
Murer, M
Ferreira, A
Mauvais, P
Bonnefoy, A
Klich, M
机构：
[1] Aventis Pharma, Med Chem, F-93235 Romainville, France
[2] Aventis Pharma, Struct Anal, F-93235 Romainville, France
[3] Aventis Pharma, Infect Dis, F-93235 Romainville, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)00257-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation constant of the resulting compounds. Antibacterial activity of the new coumarin derivatives could be correlated with the amount of uncharged form in physiological conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1461 / 1464
页数：4
相关论文
共 50 条
  • [31] Physico-chemical characterisation of a new polymorph of caffeine
    Emma Dichi
    Bernard Legendre
    Mehrez Sghaier
    Journal of Thermal Analysis and Calorimetry, 2014, 115 : 1551 - 1561
  • [32] New hydrofluoropolyethers II: Physico-chemical characterization
    Tonelli, Claudio
    Di Meo, Antonella
    Picozzi, Rosaldo
    Bassi, Mattia
    JOURNAL OF FLUORINE CHEMISTRY, 2011, 132 (05) : 356 - 362
  • [33] Metal ketoiminates as CVD and ALD precursors: Tuning physico-chemical properties
    Peeters, Daniel
    Devi, Anjana
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [34] Physico-chemical tuning of palaeogeographic shifts: Bhuj formation, Kutch, India
    Mandal, Anudeb
    Koner, Amlan
    Sarkar, Subir
    Tawfik, Hossam A.
    Chakraborty, Nivedita
    Bhakta, Saikat
    Bose, Pradip K.
    MARINE AND PETROLEUM GEOLOGY, 2016, 78 : 474 - 492
  • [35] IMPORTANCE OF PHYSICO-CHEMICAL PARAMETERS TO UNDERSTANDING OF DRUG ACTION AND TO RATIONAL DEVELOPMENT OF NEW DRUGS
    SEYDEL, JK
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1971, 10 (11) : 857 - &
  • [36] COMPARISON OF SELECTED NUTRITIONAL PARAMETERS AND PHYSICO-CHEMICAL PROPERTIES OF NEW TYPES OF WHOLEGRAIN FLOURS
    Dvorakova, Zuzana
    Slukova, Marcela
    Skrivan, Pavel
    Dvoracek, Vaclav
    PROCEEDINGS OF THE 15TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE, 2019, : 77 - 80
  • [37] SYNTHESIS AND PHYSICO-CHEMICAL PROPERTIES OF SCHIFF BASES IN BENZOTHIAZOLE SERIES
    CONTE, M
    GUGLIELM.R
    METZGER, J
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1967, (08): : 2834 - &
  • [38] Non-destructive assessment of kiwifruit physico-chemical parameters to optimise the osmotic dehydration process: A study on FT-NIR spectroscopy
    Santagapita, Patricio R.
    Tylewicz, Urszula
    Panarese, Valentina
    Rocculi, Pietro
    Dalla Rosa, Marco
    BIOSYSTEMS ENGINEERING, 2016, 142 : 101 - 109
  • [39] VARIABILITY OF SELECTED PHYSICO-CHEMICAL PARAMETERS OF WATER IN THE SLUPSKO RESERVOIR
    Moraczewska-Majkut, Katarzyna
    Jaron, Agata
    Lobos-Moysa, Ewa
    Nocon, Witold K.
    ACTA SCIENTIARUM POLONORUM-FORMATIO CIRCUMIECTUS, 2022, 21 (01) : 3 - 15
  • [40] Effects of blast fishing to some physico-chemical parameters of seawater
    Ulas, Ali
    Ozgul, Aytac
    Ilkyaz, Akin Turker
    CAHIERS DE BIOLOGIE MARINE, 2018, 59 (05): : 461 - 465
12345