Recent Developments in Liquid-State INADEQUATE Studies

This chapter covers the development and application of INADEQUATE (ADEQUATE) in high-resolution NMR spectroscopy during the period 2003-2009 Starting with the introduction of the basic concept of the technique. this chapter highlights issues related to the increasing sensitivity of INADEQUATE including the use of (1)H and (13)C optimised, cryogenically cooled probes, single-transition INADEQUATE methods, post-acquisition processing and elimination of off-resonance effects Various implementations of (1)H-detected INADEQUATE methods are compared. followed by the discussion of the techniques employed for the measurement of carbon carbon coupling constants with an emphasis on long-range couplings Recent applications of (13)C- and (1)H-detected INADEQUATE to primary structure determination of small molecules in studies of biosynthetic pathways as well as studies of fullerenes and polymers are presented The chapter concludes with the examination of several recent examples of the use of INADEQUATE to (29)Si, (15)N and (77)Se