Experimental measurement and thermodynamic modeling of Lansoprazole solubility in supercritical carbon dioxide: Application of SAFT-VR EoS

Solubility measurement of a solid solute in supercritical fluid (SCF) is considered as a primary step in micro- and nano-sized particles production through SCF technology. In this work, for the first time, solubility of Lansoprazole (LPZ) in supercritical carbon dioxide (SC-CO2) was determined at pressures and temperatures ranging within 12-27 MPa and 308.2-338.2 K, respectively. Under the applied conditions, mole fractions were obtained in the range of 1.15 x 10(-5) to 7.36 x 10(-4). For correlating the drug solubility, six semi-empirical models and two equations of state (EoSs), i.e., Peng-Robinson (PR) as a cubic EoS and SAFT-VR as a non-cubic EoSs were applied. Results showed the highest accuracy for "Reddy and Garlapati" model among semi-empirical models with AARDz of 736%. Furthermore, SAFT-VR EoS with AARD of 6.65 proved a very good priority than PR EoS and displayed the highest precision compared to all empirical models. This could be a promising application of SAFT equations to predict the thermodynamic behavior of SCFs. (C) 2019 Elsevier B.V. All rights reserved.