The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus

被引：40

作者：

Pillar, Nir ^{[1
]}

Yoffe, Liron ^{[1
]}

Hod, Moshe ^{[1
,2
]}

Shomron, Noam ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[2] Helen Schneider Hosp Women, Rabin Med Ctr, Petah Tiqwa, Israel

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2015年 / 29卷 / 02期

关键词：

preeclampsia; gestational diabetes mellitus; biomarker; early detection; microRNA; RECOMMENDATIONS; PREDICTION; MECHANISMS; EXPRESSION; ECLAMPSIA; IMPACT; TYPE-2; CELL;

D O I：

10.1016/j.bpobgyn.2014.04.021

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Great obstetrical syndromes is a collective name for several complications of pregnancy that affect >15% of pregnancies. They may confer adverse pregnancy outcomes and maternal and fetal morbidity, and require close medical monitoring and treatment. The etiology, pathogenesis, and outcome of these syndromes are obscure in the majority of cases. All appear during mid-to-late pregnancy with no reliable biomarkers for early detection and possibly prevention at present. This article focuses on the quest for early reliable markers for preeclampsia and gestational diabetes mellitus (GDM) development, mainly on the involvement of microRNA in the pathogenesis and its possible role as an early biomarker for disease development. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：176 / 182

页数：7

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