Effect of PLGA block molecular weight on gelling temperature of PLGA-PEG-PLGA thermoresponsive copolymers

被引：27

作者：

Steinman, Noam Y. ^{[1
]}

Haim-Zada, Moran ^{[1
]}

Goldstein, Isaac A. ^{[1
]}

Goldberg, Ayelet H. ^{[1
]}

Haber, Tom ^{[2
]}

Berlin, Jacob M. ^{[2
]}

Domb, Abraham J. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel

[2] City Hope Beckman Res Inst, Dept Mol Med, 1500 East Duarte Rd, Duarte, CA 91010 USA

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2019年 / 57卷 / 01期

关键词：

biodegradable polymers; copolymerization; drug delivery systems; hydrogels; PEG-PLGA; thermoresponsive hydrogels; DRUG-DELIVERY; TRIBLOCK COPOLYMER; IN-VITRO; HYDROGEL; GELATION; RELEASE;

D O I：

10.1002/pola.29275

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers exhibit a sol-gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 degrees C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 35-39

引用

页码：35 / 39

页数：5

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