Novel hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the water-soluble phosphane 1,3,5-triaza-7-phosphaadamantane:: Synthesis and evaluation of DNA binding properties

被引：26
|
作者：
Garcia-Fernandez, Almudena [1 ]
Diez, Josefina [1 ]
Manteca, Angel [2 ]
Sanchez, Jesus [2 ]
Gamasa, M. Pilar [1 ]
Lastra, Elena [1 ]
机构：
[1] Univ Oviedo, Dept Quim Organ & Inorgan, Inst Quim Organmet Enr Moles, Unidad Asoc CSIC, E-33006 Oviedo, Principado De A, Spain
[2] Univ Oviedo, Dept Biol & Func, Inst Univ Biotecnol Asturias, Area Microbiol, E-33006 Oviedo, Principado De A, Spain
来源：
POLYHEDRON | 2008年 / 27卷 / 04期
关键词：
water-soluble ruthenium(II) complexes; hydridotris(pyrazolyl)borate; PTA; DNA binding; microbial cytotoxicity;
D O I：
10.1016/j.poly.2007.12.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of half-sandwich ruthenium(H) complexes containing kappa(3) (N,N,N)-hydridotris(pyrazolyl)borate (kappa(3)(NNN)-Tp) and the water-soluble phosphane 1,3,5-triaza-7-phosphaadamantane (PTA) [RuX[kappa(3)(N,N,N)-Tp)(PPh3)(2-n)(PTA)(n)] (n = 2, X = Cl (1), n = 1, X = Cl (2), I (3), NCS (4), H (5)) and [Ru{kappa(3)(N,N,N)-Tp}(PPh3)(PTA)L][PF6] (L = NCMc (6), PTA (7)) have been synthesized. Complexes containing 1-methyl-3,5-diaza-1-azonia-7-phosphaadamantane(m-PTA) triflate [RuCl{kappa(3)(N,N,N)-Tp}(m-PTA)(2)][CF3SO3](2) (8) and [RuX{kappa(3)(N,N,N)-Tp) (PPh3)(m-PTA)][CF3SO3] (X = Cl (9), H (10)) have been obtained by treatment, respectively, of complexes 1, 2 and 5 with methyl triflate. Single crystal X-ray diffraction analysis for complexes 1, 2 and 4 have been carried out. DNA binding properties by using a mobility shift assay and antimicrobial activity of selected complexes have been evaluated. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：1214 / 1228
页数：15
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