Natural compounds: Leads or ideas? Bioinspired molecules for drug discovery

被引：71

作者：

Beghyn, Terence ^{[1
,2
,3
]}

Deprez-Poulain, Rebecca ^{[1
,2
,3
]}

Willand, Nicolas ^{[1
,2
,3
]}

Folleas, Benoit ^{[4
]}

Deprez, Benoit ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, U761, F-59006 Lille, France

[2] Univ Lille 2, Fac Pharm, F-59006 Lille, France

[3] Inst Pasteur, IFR 142, F-59021 Lille, France

[4] DIVERCHIM SA, F-60765 Montataire, France

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2008年 / 72卷 / 01期

关键词：

bicyclic-lactams; bielectrophile-binucleophile reactions; bioinspiration; biomimicry; complexity of synthesis efficiency index; spirochromanones;

D O I：

10.1111/j.1747-0285.2008.00673.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.

引用

页码：3 / 15

页数：13

共 50 条

[21] Molecular modeling in the discovery of drug leads
Milne, GWA
Wang, SM
Nicklaus, MC
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1996, 36 (04): : 726 - 730
[22] Spirotetronate Polyketides as Leads in Drug Discovery
Lacoske, Michelle H.
Theodorakis, Emmanuel A.
JOURNAL OF NATURAL PRODUCTS, 2015, 78 (03): : 562 - 575
[23] Macrocyclic marine natural products: leads in the drug discovery process for potential glioma therapeutics
Ishmael, Jane Elizabeth
Serrill, Jeffrey Daniel
Wan, Xuemei
Alani, Adam W.
McPhail, Kerry L.
FASEB JOURNAL, 2016, 30
[24] Drug Discovery - A New Bioactive Compounds Isolated from Natural Sources
Sharmaa, Richa
Choudharyb, Neeraj
Sharmac, Gajanand
ROMANIAN JOURNAL OF MILITARY MEDICINE, 2023, 126 (03) : 322 - 330
[25] Drug discovery: a new bioactive compounds isolated from natural sources
Sharma, Richa
Choudhary, Neeraj
Choudhary, Rajat
Sharma, Gajanand
IZVESTIYA VUZOV-PRIKLADNAYA KHIMIYA I BIOTEKHNOLOGIYA, 2023, 13 (01): : 28 - 37
[26] Editorial on the Special Issue "Natural Compounds Applications in Drug Discovery and Development"
Bora, Alina
Crisan, Luminita
PROCESSES, 2024, 12 (06)
[27] Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
Newman, David J.
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (09) : 2589 - 2599
[28] Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
Newman, David J.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
[29] Macrocyclic marine natural products: leads in the drug discovery process for potential glioma therapeutics
Ishmael, Jane Elizabeth
Serrill, Jeffrey Daniel
Wan, Xuemei
Alani, Adam W.
McPhail, Kerry L.
FASEB JOURNAL, 2016, 30
[30] Parsing Molecules for Drug Discovery
Walker, Allison S.
Pishchany, Gleb
Clardy, Jon
BIOCHEMISTRY, 2020, 59 (17) : 1645 - 1646

← 1 2 3 4 5 →